Last week the International Primary Immunodeficiencies Congress (IPIC 5th Edition) took place in Vilamoura, Portugal with many clinicians with an interest in primary immunodeficiencies (PIDs)/human inborn errors of immunity (IEI) alongside leading physicians in the field, patient organisation representatives, nurses, industry representatives and other interested stakeholders. Frank Staal (LUMC) also gave a presentation on Stem cell based gene therapy showing the results of the Recomb consortium. We are pleased that the project received many positive feedback from the audience. Many thanks to IPOPI for organising such a fantastic congress again!